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This report presents the design methodology of a highly integrated and radiation-tolerant software-defined radio (SDR) for multi-band radio applications for space applications. From the proposed risk-assessment methodology, the user is provided with the instruments to understand whether commercial-of-the-shelf (COTS) components would be a suitable option for the system under design or whether it would be recommended to use high-reliably, radiationhardened or space-qualified parts.